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目的:测定脱氢卡维丁的血浆蛋白结合率。方法:采用超滤法和高效液相色谱法对脱氢卡维丁的血浆蛋白结合率进行测定。结果:脱氢卡维丁与牛血清白蛋白、人血浆和大鼠血浆的蛋白结合率分别为(22.91±1.40)%、(54.35±2.95)%及(52.11±2.31)%。结论:脱氢卡维丁与血浆蛋白具有较低强度的结合。
Objective: To determine the plasma protein binding rate of dehydrocavagedine. Methods: The plasma protein binding rate of dehydrocavitine was determined by ultrafiltration and high performance liquid chromatography. Results: The protein binding rates of dehydrocavageine to bovine serum albumin, human plasma and rat plasma were (22.91 ± 1.40)%, (54.35 ± 2.95)% and (52.11 ± 2.31)%, respectively. Conclusions: Dehydrocavagedine binds to plasma proteins with lower intensity.