内质网是细胞内最重要的细胞器之一,内质网功能与细胞状态密切相关。异常蛋白在内质网的堆积、胆固醇代谢异常、钙代谢紊乱等均能引起内质网应激。内质网应激在细胞生理病理中发挥重要作用。研究表明:内质网应激与神经退行性疾病,如帕金森病密切相关。该文简单概述了内质网应激与帕金森病之间的关系。 Endoplasmic reticulum is one of the most important intracellular organelles, and the function of endoplasmic reticulum is closely related to cell status. Abnormal protein accumulation in the endoplasmic reticulum, abnormal cholesterol metabolism, calcium metabolism disorder can cause endoplasmic reticulum stress. Endoplasmic reticulum stress plays an important role in cell physiology and pathology. Studies have shown that endoplasmic reticulum stress is closely related to neurodegenerative diseases such as Parkinson’s disease. This article briefly outlines the relationship between endoplasmic reticulum stress and Parkinson’s disease.