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溃疡病是一常见病、多发病,其病因和发病原理还未完全清楚,其防治亦不够满意。长期以来国内外对此疾病积累了大量的材料,现和大家一起温习一下近年来对此病的病因发病原理和治疗的一些有代表性的进展。关于病因和发病原理方面一、关于胃粘膜屏障,氢离子回渗和幽门运动功能失常正常胃粘膜具有阻止对其有害的物质进入胃粘膜的能力,称胃屏障。胃屏障的一个重要作用是防止胃腔里的盐酸,即氢离子从胃腔回渗(Back diffusion)到胃粘膜细胞里。大家都知道,胃液的酸度是高的,其氢离子的浓度与血浆和胃粘膜细胞的氢离子浓度之比为1,000,000比1。这一很陡的阶度是由于氢离子主动分泌到胃腔内而做成;维持这一阶度则是防止氢离子的回渗这一道屏障。如果这一屏障受到破坏,则氢离子便向胃粘膜细胞内回渗,这不仅使胃腔内的氢离子浓度减低,亦即酸度减低而不能反映分泌的原来真实情况;同时胃粘膜细胞亦因其细胞内的氢离子浓
Canker disease is a common disease, frequently-occurring disease, its etiology and pathogenesis has not yet fully understood, its control is not satisfactory. For a long time this disease has accumulated a large amount of materials both at home and abroad, and now we are reviewing some of the pathogenesis and treatment of the disease in recent years some representative progress. On the etiology and pathogenesis First, on the gastric mucosal barrier, hydrogen ion reabsorption and pyloric dysfunction Normal gastric mucosa to prevent the harmful substances into the gastric mucosa, called the gastric barrier. An important role of the gastric barrier is to prevent hydrochloric acid in the gastric cavity, that is, hydrogen ions from diffusing back into gastric mucosal cells. As we all know, gastric acidity is high, and the ratio of its hydrogen ion concentration to the hydrogen ion concentration of plasma and gastric mucosal cells is 1,000,000 to 1. This very steep grade is due to the active secretion of hydrogen ions into the stomach cavity; to maintain this level is to prevent hydrogen ion re-seepage barrier. If this barrier is damaged, the hydrogen ions will re-enter the gastric mucosal cells, which not only reduces the concentration of hydrogen ions in the gastric cavity, that is, the acidity decreased and can not reflect the original secretory secretion; the same time, gastric mucosal cells also due to Its intracellular hydrogen ion concentration