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[目的]观察养阴化瘀汤联合西药治疗慢性乙型肝炎早期肝硬化疗效。[方法]使用随机平行对照方法,将78例住院患者按抛硬币法简单随机分为两组。对照组39例恩替卡韦,0.5g/次,1次/d。治疗组39例养阴化瘀汤(枸杞、制首乌、女贞子、鳖甲炙、丹参各20g,生地、赤白芍各15g,当归、莪术各10g;肝郁不舒加郁金、柴胡各10g;腹水去生地,加茯苓、泽泻各15g;出血加地榆30g;腹胀加枳壳6g);1剂/d,水煎200m L,1次/d;西药治疗同对照组。连续治疗30d为1疗程。观测临床症状、谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TBIL)、透明质酸(HA)、层黏连蛋白(LN)、Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(CⅣ)、不良反应。连续治疗3疗程,判定疗效。[结果]治疗组显效15例,有效19例,无效5例,总有效率87.18%。对照组显效11例,有效15例,无效13例,总有效率66.67%。治疗组疗效优于对照组(P<0.05)。相关指标治疗组改善优于对照组(P<0.05)。[结论]养阴化瘀汤联合西药治疗慢性乙型肝炎早期肝硬化疗效满意,无严重不良反应,值得推广。
[Objective] To observe the curative effect of Yangyin Huayu Decoction combined with western medicine on early cirrhosis of chronic hepatitis B. [Methods] Randomized parallel method was used to divide 78 hospitalized patients into two groups according to the coin-tossing method. Control group, 39 cases of entecavir, 0.5g / time, 1 / d. The treatment group 39 cases of yin and blood stasis soup (wolfberry, Shouwu, Ligustrum, turtle Burn, Salvia the 20g, habitat, red peony root of the 15g, Angelica, Curcuma 10g; liver depression is not comfortable with turmeric, Bupleurum each 10g; ascites to habitat, plus Poria, Alisma each 15g; hemorrhage plus Burnet 30g; abdominal distension plus Citrus aurantium 6g); 1 / d, decoction 200m L, 1 / d; Western medicine treatment with the control group. Continuous treatment of 30d for a course of treatment. The clinical symptoms, ALT, AST, TBIL, HA, LN, PCⅢ, Collagen (C Ⅳ), adverse reactions. Continuous treatment of 3 courses to determine the efficacy. [Result] In the treatment group, 15 cases were markedly effective, 19 cases were effective, 5 cases were ineffective, and the total effective rate was 87.18%. In the control group, 11 cases were markedly effective, 15 cases were effective, 13 cases were ineffective, and the total effective rate was 66.67%. The treatment group was better than the control group (P <0.05). Correlation index treatment group improved better than the control group (P <0.05). [Conclusion] Yang-Yin-Huayu Decoction combined with western medicine is effective in treating early-stage cirrhosis of chronic hepatitis B without serious adverse reactions and is worth promoting.