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目的:对头孢吡肟引起神经毒性的国内外文献进行统计分析,提示临床应用注意本药可导致神经毒性,避免引起严重后果。方法:利用中国期刊网数据库和Pubmed检索1999～2009年报道静滴头孢吡肟引起神经毒性不良反应的文献,分析其引起神经毒性的规律和特点。结果:共检索到头孢吡肟引起神经毒性的文献71篇,中文文献53篇,英文文献18篇。其中个例报道36例。头孢吡肟引起神经毒性发病年龄平均为64.5岁,1例高龄患者死亡,死亡率为2.8%。结论:头孢吡肟引起神经毒性与患者年龄和肾功能密切相关,与患者性别、给药剂量无明显相关性。
OBJECTIVE: To make a statistical analysis of the literature about the toxicity caused by cefepime in the world, suggesting that the drug can cause neurotoxicity in clinical application and avoid serious consequences. Methods: The Chinese Journal Net Database and Pubmed were used to search the literature about the adverse effects of intravenous cefepime on neurotoxicity reported from 1999 to 2009, and to analyze the regularity and characteristics of their neurotoxicity. Results: A total of 71 articles of cefepime-induced neurotoxicity were retrieved, 53 articles in Chinese and 18 articles in English. One case reported 36 cases. Cefepime cause neurotoxicity The average age of onset is 64.5 years old, 1 case of elderly patients died, the mortality rate was 2.8%. Conclusion: Cefepime-induced neurotoxicity is closely related to patient’s age and renal function, and has no significant correlation with patient’s sex and dosage.