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目的:探讨胃腺癌患者和正常人的舌苔形成与血清sE-cad水平的相关性.方法:采用临床病例-对照法,应用ELISA测定266例胃腺癌患者和252例对照人群的血清sE-cad水平,非参数检验分析血清sE-cad水平、临床检验指标和舌苔类型的相关性.结果:胃腺癌组血清sE-cad水平显著高于对照组(P<0.01),术前者血清sE-cad水平显著高于术后者(P<0.05),胃腺癌未转移者血清sE-cad水平显著高于转移者(P<0.05).胃腺癌组血清sE-cad水平表现为白厚苔>白薄苔>黄厚苔>黄薄苔>剥苔,有统计学意义(P<0.05),对照组血清sE-cad水平表现为黄薄苔>黄厚苔>白薄苔>白厚苔>剥苔,但无统计学意义(P>0.05).胃腺癌组临床检验指标异常者比例均高于对照组(P<0.05),特别是总蛋白异常的厚苔、薄苔胃腺癌患者的血清sE-cad水平均高于总蛋白异常的厚苔、薄苔对照组(P<0.05).结论:胃腺癌患者苔质厚薄变化、血清总蛋白和sE-cad水平检测对临床胃腺癌防治可能有重要的临床价值.
Objective: To investigate the relationship between the formation of tongue coating and the level of serum sE-cad in patients with gastric adenocarcinoma and normal subjects.Methods: Serum sE-cad levels were measured in 266 patients with gastric adenocarcinoma and 252 controls by ELISA using clinical case-control method , Non-parametric test analysis of serum sE-cad levels, clinical test parameters and the type of tongue coating.Results: The serum sE-cad level in gastric adenocarcinoma group was significantly higher than that in the control group (P <0.01) (P <0.05), and the level of sE-cad in gastric adenocarcinoma without metastasis was significantly higher than that in metastasis (P <0.05) .The level of sE-cad in gastric adenocarcinoma showed as follows: white thick moss> white thin moss> yellow thick moss (P> 0.05). The levels of serum sE-cad in the control group showed yellowish moss> yellow moss> white moss> white moss> peal moss, but there was no statistical significance (P> 0.05) .The proportion of clinical abnormalities in gastric adenocarcinoma group was higher than that in control group (P <0.05), especially in patients with thick-moss and poor-moss gastric adenocarcinoma with total protein abnormalities (P <0.05) .Conclusion: The changes of the thickness of the gingival callus, the levels of serum total protein and sE-cad in patients with gastric adenocarcinoma Clinical prevention and treatment of gastric cancer could have important clinical value.