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Resonant magnetic perturbations (RMPs) are extensively applied to mitigate or suppress the edge localized mode in tokamak plasmas,but will break the axisymmetric magnetic field configuration and increase the loss of energetic ions.The mechanism of RMPs induced energetic ion loss has been extensively studied,and is mainly attributed to resonant effects.In this paper,in the perturbed non-axisymmetric tokamak pedestal,we analytically derive the equations of guiding center motion for energetic ions including the bounce/transit averaged radial drift velocity and the toroidal precession frequency modified by strong radial electric field.The loss time of energetic ions is numerically solved and its parametric dependence is analyzed in detail.We find that passing energetic ions cannot escape from the plasma,while deeply trapped energetic ions can escape from the plasma.The strong radial electric field plays an important role in modifying the toroidal precession frequency and resulting in the drift loss of trapped energetic ions.The loss time of trapped energetic ions is much smaller than the corresponding slowdown time in DIII-D pedestal.This indicates that the loss of trapped energetic ions in the perturbed non-axisymmetric pedestal is important,especially for the trapped energetic ions generated by perpendicular neutral beam injection.