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为了探讨综合驱铜治疗对具有不同肝脾声像图分型的肝豆状核变性 ( HLD)患者胆汁排铜及肝脾声像图指标的影响。我们采用二巯丁二酸和二巯丙磺钠治疗 30例 HLD,治疗前后用 Aloka SSD2 56型声像图仪对患者进行声像图分型和测量 ,并施行 12指肠引流术留取胆汁 B液检测铜、锌、铁含量。结果综合驱铜能有效地增加光点闪烁型、岩层征型和树枝状光带型患者的胆汁铜排泄 ( P<0 .0 0 1) ,且树枝状光带型的 SPT、SPLb、SV、PV较疗前显著改善 ( P<0 .0 1) ,而结节型患者胆汁铜排泄未见明显改善 ,仅疗后 SV、PV有显著性改善 ( P<0 .0 5)。认为综合驱铜能明显地促进肝硬化前期及早、中期 HLD患者肝胆铜排泄 ,并有效地改善患者的肝硬化超声指标
In order to investigate the effect of comprehensive copper-driven therapy on bile copper excretion and liver and spleen sonography in hepatolenticular degeneration (HLD) patients with different liver and spleen sonography. We used dimercaptosuccinic acid and sodium dimercaptopropionate treatment of 30 cases of HLD, before and after treatment with Aloka SSD2 56 sonography of patients with sonographic mapping and measurement, and the implementation of 12-year-term drainage of the bile duodenal drainage B liquid detection of copper, zinc, iron content. Results The comprehensive flooding of copper could effectively increase the bile copper excretion (P <0. 001) in the blinking, rock stratification and dendritic bands, and the SPT, SPLb, SV, PV significantly improved before treatment (P <0.01), while no significant improvement in bile copper excretion was seen in patients with nodular disease. The SV and PV were significantly improved only after treatment (P <0.05). That the comprehensive drive copper can significantly promote early and early cirrhosis of liver cirrhosis patients with hepatobiliary excretion of copper, and effectively improve the patient’s liver ultrasound index