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目的:观察大剂量醛氢叶酸(CF)联合5-氟尿嘧啶(5-FU)静脉注射和连续静脉滴注,低量顺铂(DDP)连续静滴加腹腔化疗治疗晚期胃癌的近期疗效。方法:对29例晚期胃癌应用CF200mg/(m2·d),静脉滴注2h,以后5-FU400mg/m2即刻注射,随后以5-FU250mg/m2,连续静脉滴注,持续22h,连用3d,DDP10mg/(m2·d)连续静滴3d,丝裂霉素(MMC)10mg,羟基喜树碱(HCPT)20mg加入生理盐水1500～2500ml,灌注入腹腔,每2周1次,2次为1个周期,6周期判定疗效。结果:完全缓解(CR)2例,部分缓解(PR)14例,稳定(NC)10例,进展(PD)3例,有效率为55%,不良反应主要为白细胞减少,轻度胃肠道反应,口腔黏膜炎。结论:大剂量CF联合5-FU,低量顺铂加腹腔化疗治疗晚期胃癌有较好疗效,不良反应小,提高患者的生存质量。
OBJECTIVE: To observe the short-term curative effect of high-dose intravenous infusion of doxorubicin (CF) combined with 5-fluorouracil (5-FU) and continuous intravenous infusion of low dose cisplatin (DDP) plus intraperitoneal chemotherapy for advanced gastric cancer. Methods: 29 cases of advanced gastric cancer were treated with CF200mg / (m2 · d) intravenously for 2h. Immediate injection of 5-FU400mg / m2 followed by continuous intravenous infusion of 5-FU250mg / m2 for 22h. / (m2 · d) for 3 consecutive days, mitomycin (MMC) 10mg, hydroxycamptothecin (HCPT) 20mg normal saline 1500 ~ 2500ml, perfusion into the abdominal cavity, once every 2 weeks, 2 times for a Period, 6 cycles to determine the efficacy. Results: There were 2 cases of complete remission (CR), 14 cases of partial remission (PR), 10 cases of stable (NC) and 3 cases of progressive (PD). The effective rate was 55%. The main adverse reactions were leukopenia, mild gastrointestinal Response, oral mucositis. Conclusion: High-dose CF combined with 5-FU, low-dose cisplatin plus intraperitoneal chemotherapy for advanced gastric cancer have better curative effect, less adverse reactions, and improve the quality of life of patients.