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目的 探讨晚期胰腺癌围手术期免疫调节治疗效果.方法 43例晚期胰腺癌随机分为香菇多糖综合治疗组和对照组,动态观察术后T细胞亚群、NK细胞活性的变化,比较两组病人的生存期.结果 香菇多糖综合治疗组术后NK活性、CD_3、CD_4细胞数和CD_4/CD_8比值较对照组明显升高(P<0.05);术后平均生存期(14.9±8.5)月,明显高于对照组(7.7±3.5)月(P<0.001).结论 晚期胰腺癌患者围手术期免疫调节综合治疗,有助于改善机体细胞免疫功能和提高病人生存期.
Objective To investigate the effect of perioperative immunoregulatory therapy for advanced pancreatic cancer. Methods Forty-three cases of advanced pancreatic cancer were randomly divided into lentinan treatment group and control group. The dynamic changes of T cell subsets and NK cell activity were observed and compared between the two groups of patients. Survival period. Results The NK activity, CD3, CD4 cell count, and CD4/CD8 ratio in the lentinan treatment group were significantly higher than those in the control group (P<0.05); the average survival time was (14.9±8.5) months. It was higher than the control group (7.7±3.5) months (P<0.001). Conclusion The comprehensive treatment of perioperative immune regulation in patients with advanced pancreatic cancer is helpful to improve the cellular immune function and improve the patient’s survival period.