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作者报导1例AIDS患者在接受神经松弛剂(NP)治疗后发生基底神经节障碍的NP恶性综合征(MS)。 26岁女性黑人,配偶为异性恋,他有发热、口腔念珠菌病、腹痛和不愈合的外阴切开术后疤痕。患者有T-辅助淋巴细胞完全缺损的淋巴细胞减少及HTLV-Ⅲ抗体。住院第15天的血和骨髓培养有荚膜组织胞浆菌,在发现该菌感染之前,住院次日发生恶心和呕吐,应用甲哌氯丙嗪,三甲氧苯酰胺和达哌啶醇等安适剂作间断性治疗。在用甲哌氯丙嗪后第5天,CPK升到372U/L,第12住院日发生类偏执观念,复查CPK高达2512U/L,为治疗精神症状用达哌啶醇静注和肌注,但当夜即发生无动性缄默(AM),两上肢静止性细小震颤和齿轮样强直,
The authors report an NP malignant syndrome (MS) in AIDS patients with basal ganglia dysfunction following neuroleptic (NP) treatment. 26-year-old female black, spouse heterosexual, he has fever, oral candidiasis, abdominal pain and non-healing vulvar incision scar. Patients with T-helper lymphocytes complete defect of lymphopenia and HTLV-III antibody. On the 15th day of hospitalization, blood and bone marrow were cultured with Histoplasma capsulatum. Before the infection of the bacteria was found, the patient developed nausea and vomiting on the next day of hospitalization. The patients were treated with chlorpromazine, trimethoprim and dapperidol Agent for intermittent treatment. On the fifth day after treatment with prochlorperazine, the CPK rose to 372 U / L. On the 12th day of hospitalization, the concept of paranoid type paranoid occurred. The CPK was as high as 2512 U / L, intravenous injection of pethidine and intramuscular injection for the treatment of psychiatric symptoms, But that night there is no incentive to silence (AM), two upper extremity resting tremors and gear-like ankylosis,