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AIM: To evaluate the effect of age and acoustic stress on gastric myoelectrical activity (GMA) and autonomic nervous system function,METHODS: Twenty-one male subjects (age range 22-71years, mean 44 years) were recruited and exposed, in random order, to three auditory stimuli (Hospital noise,conversation babble and traffic noise) after a 20-min baseline. All periods lasted 20 min and were interspersed with a 10 min of recovery. GMA was obtained using a Synectics Microdigitrapper. Autonomic nerve function was assessed by monitoring blood pressure and heart rate using an automatic recording device.RESULTS: Dominant power tended to decrease with increase of age (P＜0.05). The overall percentage of three cycle per minute (CPM) activity decreased during exposure to hospital noise (12.0%, P ＜ 0.05), traffic noise (13.9%, P ＜ 0.05), and conversation babble(7.1%). The subjects in the younger group (＜ 50 years)showed a consistent reduction in the percentage of 3CPM activity during hospital noise (22.9%, P ＜ 0.05),traffic noise (19.0%, P ＜ 0.05), and conversation babble(15.5%). These observations were accompanied by a significant increase in bradygastria: hospital noise (P＜ 0.05) and traffic noise (P ＜ 0.05). In contrast, the subjects over 50 years of age did not exhibit a significant decrease in 3 CPM activity. Regardless of age, noise did not alter blood pressure or heart rate.CONCLUSION: GMA changes with age. Loud noise can alter GMA, especially in younger individuals. Our data indicate that even short-term exposure to noise may alter the contractility of the stomach.