肥胖及其相关疾病已经成为全球的公共卫生问题,越来越多的研究提示肥胖对环境污染物所致健康损伤的易感性都有所增加,其机制可能与环境污染物在脂肪组织中的蓄积、肥胖诱发氧化应激和炎症以及细胞色素P450代谢酶的活力改变有关,但也有研究提示肥胖可以增加机体对环境毒物的耐受性。因此,笔者主要就超重或肥胖对环境因素所致呼吸系统、心血管系统、生殖系统、肝脏以及神经系统等损害的易感性进行了综述,并提出可能的机制,旨在为超重或肥胖患者的健康保护策略提供依据。 Obesity and its related diseases have become global public health problems. More and more studies have suggested that the susceptibility of obesity to health damage caused by environmental pollutants has increased. The mechanism may be related to the accumulation of environmental pollutants in adipose tissue , Obesity-induced oxidative stress and inflammation, and changes in the activity of cytochrome P450 metabolic enzymes, but studies have suggested that obesity may increase the body’s tolerance to environmental toxicants. Therefore, the author mainly reviews the susceptibility of overweight or obesity to environmental factors such as respiratory system, cardiovascular system, reproductive system, liver and nervous system damage and proposes possible mechanisms aimed at overweight or obese patients Health protection strategy to provide the basis.