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在不同的 Fc 受体或特异性细胞表面抗原的基础上曾经鉴定了人类 T 细胞亚群。在这一研究中,我们使用了一系列与 T 细胞、单核细胞和 Ia 抗原起反应的单克隆抗体,以鉴别带有 IgG(T_γ)Fc 受体的 T 细胞亚群和带有IgM(T_μ)Fc 受体的 T 细胞亚群。结果表明,T_μ亚群含有诱导者(OKT 4~+)和细胞毒/抑制者(OKT 5~+)群,并与未组分 T 细胞群相似;而 T_γ亚型含有极少的 T 淋巴细胞(OK-T 3~+)且不富含用这些单克隆抗体鉴定的 T细胞亚型。当然,T_γ群包含大量具有单核细胞抗原(OKM1~+)的Ⅰα~-细胞。在与此相反的研究中,发现分离的 OKT 4~+和 OKT 5~+T 细胞亚型很少含有 T_γ细胞,而这两个亚型主要由 T_μ细胞组成。我们的结论是,在这些单克隆抗体和 Fc 受体所鉴定的 T 细胞亚型之间的相互关系是很少的。
Human T-cell subsets have been identified on the basis of different Fc receptors or specific cell surface antigens. In this study, we used a series of monoclonal antibodies reactive with T cells, monocytes and Ia antigens to identify T cell subsets with IgG (T_γ) Fc receptors and T cells with IgM (T_μ ) T cell subsets of Fc receptors. The results showed that the T_μ subpopulation contained OKT 4 ~ + and cytotoxic / suppressive (OKT 5 ~ +) populations, which were similar to the non-T cell population, while the T_γ subtype contained very few T lymphocytes (OK-T 3 ~ +) and is not rich in T-cell subtypes identified with these monoclonal antibodies. Of course, the T_γ population contains a large number of Iα ~ - cells with monocyte antigens (OKM1 ~ +). In the opposite study, it was found that isolated OKT 4 ~ + and OKT 5 ~ + T cell subsets seldom contain T_γ cells, whereas the two isoforms mainly consist of T_μ cells. We conclude that there is very little correlation between the T-cell subtypes identified by these monoclonal antibodies and Fc receptors.