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下丘脑-垂体-卵巢轴直接调控月经周期，三者之间通过促性腺激素与卵巢甾体激素对下丘脑、垂体产生的反馈机制产生生理性周期变化，卵巢局部产生众多的肽类因子形成卵巢内自分泌／旁分泌调节系统，参与垂体促性腺激素性腺内作用机制的调控。
Hypothalamus - pituitary - ovarian axis directly regulate the menstrual cycle, between the three by gonadotropin and ovary steroid hormone on the hypothalamus, pituitary feedback mechanism to produce physiological cycles, the ovarian local produce a large number of peptide factors ovarian Endocrine / paracrine regulation system, involved in the regulation of pituitary gonadotrophin gonadal mechanism.