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目的探讨p53、Bcl-2和Ki-67表达与综合方法治疗皮肤基底细胞癌疗效的相关性。方法收集2012年1月-2015年4月来该院就诊的皮肤基底细胞癌患者46例,统一给予5-氨基酮戊酸光动力疗法、手术及咪喹莫特等综合疗法治疗,观察患者治疗效果并分为有效组和无效组,比较2组患者治疗前后组织p53、Bcl-2和Ki-67的表达水平,分析其相关性。结果有效组患者p53、Bcl-2和Ki-67的组织表达程度明显低于无效组,差异均有统计学意义(P<0.05)。针对患者p53、Bcl-2和Ki-67的组织表达程与疗效进行Logistic回归分析,均有统计学意义(P<0.05),且各项分子最大似然估计值和OR值均<0。结论皮肤基底细胞癌患者综合方法治疗后其疗效与组织p53、Bcl-2和Ki-67表达水平呈负相关。
Objective To investigate the relationship between the expression of p53, Bcl-2 and Ki-67 in the treatment of skin basal cell carcinoma. Methods Forty-six patients with cutaneous basal cell carcinoma who were admitted to our hospital from January 2012 to April 2015 were enrolled in this study. They were given 5-aminolevulinic acid photodynamic therapy, surgery and imiquimod and other combined therapies to observe the therapeutic effect The patients were divided into active group and inactive group. The expression of p53, Bcl-2 and Ki-67 in two groups before and after treatment were compared and analyzed. Results The expression of p53, Bcl-2 and Ki-67 in effective group was significantly lower than that in ineffective group (P <0.05). Logistic regression analysis showed that the expression of p53, Bcl-2 and Ki-67 in the patients were statistically significant (P <0.05), and the maximum likelihood of each molecule and OR were <0. Conclusion The curative effect of the combined treatment of patients with cutaneous basal cell carcinoma is negatively correlated with the expression of p53, Bcl-2 and Ki-67.