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目的评价和比较奥美拉唑+丽珠胃三联、奥美拉唑+阿莫西林+甲硝唑、丽珠胃三联、三种治疗方案对HP阳性糜烂性胃炎的治疗效果和对幽门螺杆菌的根除情况。方法50例经胃镜证实糜烂性胃炎伴HP感染的患者随机分成三组:A组15例,奥美拉唑20mg+枸橼酸铋钾220mg+克拉霉素250mg+替硝唑500mg,每日2次,共用7天;B组19例,奥美拉唑20mg+阿莫西林1000mg+甲硝唑400mg,每日2次,共用7天;C组18例,枸橼酸铋钾220mg+克拉霉素250mg+替硝唑500mg,每日2次,共用7天。治疗后,停药4周复查胃镜,观察HP根除率及糜烂性胃炎愈合情况。结果进行统计学分析,应用χ2检验。结果HP根除率A、B、C三组分别为93.3%、84.2%、83.3%,糜烂性胃炎的治愈率分别为86.7%、78.9%、77.8%,各组间差异无统计学意义(P>0.05)。结论丽珠胃三联1周治疗方案具有药物剂量小,疗程短,价格低,疗效好特点,对于根除HP治愈糜烂性胃炎具有较好的效果。
Objective To evaluate and compare the therapeutic effect of omeprazole + Livzon triplex, omeprazole + amoxicillin + metronidazole and liguzhu triple therapy on HP-positive erosive gastritis and the effect of Helicobacter pylori Eradication of the situation. Methods Fifty patients with erosive gastritis and HP infection confirmed by endoscopy were randomly divided into three groups: group A (n = 15), omeprazole 20 mg + bismuth potassium citrate 220 mg + clarithromycin 250 mg + tinidazole 500 mg twice daily 7 days; group B 19 cases, omeprazole 20mg + amoxicillin 1000mg + metronidazole 400mg, 2 times a day for 7 days; C group 18 cases, bismuth potassium citrate 220mg + clarithromycin 250mg + tinidazole 500mg , 2 times a day, sharing 7 days. After treatment, 4 weeks review of gastroscope, observe the eradication rate of HP and erosive gastritis healing. The results of statistical analysis, the application of χ2 test. Results The eradication rates of HP were 93.3%, 84.2% and 83.3% in group A, B and C respectively. The eradication rates of erosive gastritis were 86.7%, 78.9% and 77.8%, respectively. There was no significant difference between groups (P> 0.05). Conclusion Livzon triple therapy with ligation of the stomach with a small dose of medication, short course, low price, good efficacy characteristics, for the eradication of erosive gastritis HP has a good effect.