论文部分内容阅读
目的 :探讨胰岛素样生长因子 - 1(IGF- 1)和生长激素 (GH)与 2型糖尿病 (DM)合并糖尿病肾病 (DN)的关系。方法 :1采用免疫放射分析法检测血清 IGF- 1水平 ;2采用放射免疫分析法检测 GH和尿清蛋白。结果 :方差分析显示 :1DN组 (79例 )、非 DN组 (79例 )与健康对照组 (5 0例 )之间血清 IGF- 1水平有显著性差异 (F=9.15 ,P=0 .0 0 0 2 ) ,DN组明显高于非 DN组和对照组 ,后两组间无显著性差异 ;2 DN1组 (2 7例 )、非 DN1组 (17例 )和对照 1组 (2 0例 )间血清 GH水平无显著性差异 (F=0 .93,P>0 .0 5 ) ,同时 3组间 IGF- 1水平有显著性差异 (F=4.5 6 ,P<0 .0 5 ) ,DN1组 IGF- 1水平明显高于非 DN1组和对照 1组。结论 :IGF- 1与 2型 DM肾病有关 ,可能参与其发生和发展 ;GH与其无显著性关系。
Objective: To investigate the relationship between insulin-like growth factor-1 (IGF-1) and growth hormone (GH) and type 2 diabetes mellitus (DM) with diabetic nephropathy (DN). Methods: 1 Serum IGF-1 levels were measured by immuno-radioactive assay; 2 GH and urinary albumin were detected by radioimmunoassay. Results: ANOVA showed that serum IGF-1 levels were significantly different between the 1-DN group (79 cases), the non-DN group (79 cases) and the healthy control group (50 cases) (F = 9.15, P = DN group was significantly higher than the non-DN group and the control group, no significant difference between the two groups; DN1 group (27 cases), non-DN1 group (17 cases) and control group 1 (20 cases (F = 0.93, P> 0.05). There was also a significant difference in IGF-1 levels between the three groups (F = 4.56, P <0.05) The level of IGF-1 in DN1 group was significantly higher than that in non-DN1 group and control group 1. Conclusion: IGF-1 is associated with type 2 DM nephropathy, which may be involved in the occurrence and development of IGF-1. GH has no significant relationship with it.