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目的:探讨白细胞介素-6(IL-6)和白细胞介素-8(IL-8)与早产儿发生呼吸窘迫综合征(RDS)的关系,为RDS的防治提供参考。方法:2011~2013年在医院出生并收治于新生儿重症监护室的早产儿97例,生后2 h取股静脉血,采用流式细胞仪测定血浆IL-6、IL-8水平。按是否发生RDS将患儿分为两组,观察组31例为发生RDS患儿,其中轻度RDS 14例,重度RDS 17例;对照组66例为非RDS患儿。比较RDS与非RDS以及轻度RDS与重度RDS患儿的IL-6、IL-8水平。结果:观察组IL-6(1 952.3±243.3)pg/ml、IL-8(1 523.2±252.2)pg/ml明显高于对照组(57.8±11.5)pg/ml和(69.3±9.4)pg/ml,差异均有统计学意义(P<0.01);观察组中重度RDS患儿IL-6(2 443.4±232.4)pg/ml、IL-8(1 776.5±243.3)pg/ml明显高于轻度RDS患儿(1 356.0±255.4)pg/ml和(1 235.6±263.5)pg/ml,差异有统计学意义(P<0.05)。结论:早产儿早期测定血浆IL-6、IL-8水平可用来预测RDS的发病,在临床上有一定的参考价值。
Objective: To investigate the relationship between interleukin-6 (IL-6) and interleukin-8 (IL-8) and respiratory distress syndrome (RDS) in premature infants and to provide reference for the prevention and treatment of RDS. Methods: Ninety-seven premature infants born in hospital from 2011 to 2013 and admitted to neonatal intensive care unit were enrolled in this study. Blood samples of femoral vein were collected 2 h after birth and plasma IL-6 and IL-8 levels were measured by flow cytometry. According to whether RDS occurred or not, the children were divided into two groups. The observation group consisted of 31 patients with RDS. Among them, 14 were mild RDS and 17 were severe RDS. 66 patients in the control group were non-RDS children. IL-6 and IL-8 levels were compared between children with RDS and non-RDS, as well as with mild RDS and severe RDS. RESULTS: The levels of IL-6 (1 952.3 ± 243.3) pg / ml and IL-8 (5223.2 ± 252.2) pg / ml in the observation group were significantly higher than those in the control group (57.8 ± 11.5) pg / ml and (69.3 ± 9.4) ml, the differences were statistically significant (P <0.01). IL-6 (2 443.4 ± 232.4) pg / ml and IL-8 (776.5 ± 243.3) pg / ml in the observation group were significantly higher than those in the mild The difference was statistically significant (P <0.05) in children with degree RDS (1 356.0 ± 255.4) pg / ml and (1 235.6 ± 263.5) pg / ml. Conclusion: The levels of plasma IL-6 and IL-8 in early stage of preterm infants can be used to predict the incidence of RDS, which is of clinical significance.