【摘 要】
：
细胞色素P 4501 A 1（cytochrome P 4501 A 1，CYP1 A 1）、细胞色素P 4501 B 1（cytochrome P 4501 B 1，CYP1 B 1）、血管内皮细胞生长因子(vascular endothelial growth factor，VEGF)以
【机 构】
：
内蒙古医科大学药学院药学院，内蒙古呼和浩特，010110;内蒙古精神卫生中心精神科，内蒙古呼和浩特，010000
论文部分内容阅读
细胞色素P 4501 A 1（cytochrome P 4501 A 1，CYP1 A 1）、细胞色素P 4501 B 1（cytochrome P 4501 B 1，CYP1 B 1）、血管内皮细胞生长因子(vascular endothelial growth factor，VEGF)以及碳酸酐酶Ⅸ（carbonic anhydrase Ⅸ，CAⅨ）分别是芳香族化合物受体(aryl hydrocarbon receptor,AhR）信号通路和缺氧诱导因子(hypoxia inducible factor，HIF-1)信号通路的下游基因，这些基因的异常表达被认为与肺癌的发生、发展及血管的形成有着密切的关系。本文对CYP1 A 1、CYP1 B 1、VEGF、CAⅨ与肺癌的关系进行综述，旨在于为肺癌研究提供新思路。“,”Cytochrome P 4501 A 1, Cytochrome P 4501 B 1,Vascular endothelial growth factorand carbonic anhydrase Ⅸ belong to the downstream genes of aryl hydrocarbon receptor (AhR)and hypoxia inducible factor 1(HIF-1)signaling pathways. The abnormal expression of those genes were regarded to associated with the occurrence,development and angiogenesis of lung cancer. In this paper, the relationship between CYP1 A 1,CYP1 B 1,VEGF,CAⅨgenes and lung cancer was summarized, which aims to provide new ideas for lung cancer research.
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