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作者采集58例日本病人的80个肝脏标本。使用Wahl等改良的Southern Blot技术进行研究。结果25例肝细胞癌病人中发现12例有HBV DNA整合,12例肝硬化病人中5例有HBV DNA整合。在这17例病人中发现11例血清HBsAg阳性,余下6例血清HBV相关抗体一个以上阳性。所有3例慢性肝炎和18例对照组未测到HBV DNA整合。15例血清HBsAg阳性的病例中12例发现游离HBV DNA。1例血清HBsAg阴性的病人,其
The authors collected 80 liver specimens from 58 Japanese patients. The study was performed using a modified Southern Blot technique such as Wahl. Results Of the 25 patients with hepatocellular carcinoma, 12 were found to have HBV DNA integration and 5 of 12 patients with cirrhosis had HBV DNA integration. Of these 17 patients, 11 were found to be positive for HBsAg, and the remaining 6 were positive for HBV-related antibodies. No HBV DNA integration was detected in all 3 cases of chronic hepatitis and 18 controls. Of the 15 cases with serum HBsAg positive, 12 cases were found to have free HBV DNA. One patient with serum HBsAg negative, which