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复方喘敌素是由喘敌素为主药与其他六种药物组成的。在离体实验中,它可以直接松弛豚鼠气管和肺条,这一作用与喘敌素无明显差别。但是,对于在体外由乙酰胆碱、组胺、氯化钾和氯化钡引起的气管的痉挛性收缩,复方喘敌素的平喘作用分别比喘敌素强62、27、8、13倍。复方喘敌素对于药物引起的豚鼠哮喘有明显的保护作用,这一作用比喘敌素强7倍.复方喘敌素抑制大鼠PCA 的 ID_(50)为4μg/kg,喘敌素的 ID_(50)为300μg/kg.复方喘敌素抑制由组胺和5-羟色胺引起的大鼠皮肤血管通透性增加的作用比喘敌素强。复方喘敌素小鼠灌胃的 LD_(50)为552.9±32.2mg/kg。
Compound Astragalosin is mainly composed of cholecystokinin and six other drugs. In vitro experiments, it can directly release the guinea pig trachea and lungs, this role and no obvious difference between asthma. However, the antiasthmatic effect of compound cholecarnide was 62, 27, 8, and 13 times stronger than that of chlordane, respectively, on the spastic contraction of the trachea caused by acetylcholine, histamine, potassium chloride and barium chloride in vitro. Compound asthmatic antagonist for drug-induced guinea pig asthma has a significant protective effect, this effect is stronger than chymatis 7 times.Compound asthmaticin inhibits rat PCA ID_ (50) of 4μg / kg, chlordiazepoxide ID_ (50) of 300 μg / kg.Compound cholecystokinin inhibited histamine and serotonin-induced rat skin vascular permeability increased role than that of chlordiazepoxide. Compound asthmatic mice intragastric LD_ (50) was 552.9 ± 32.2mg / kg.