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目的:研究葡醛内酯对癫痫患者体内丙戊酸血药浓度的影响。方法:从药物相互作用角度,探讨性分析临床1例癫痫患者服用葡醛内酯对丙戊酸血药浓度影响的机制。结果:联合用药是影响丙戊酸体内血药浓度的主要因素之一,葡醛内酯可能降低丙戊酸血药浓度,影响其疗效。结论:临床对癫痫患者采用联合用药治疗时,应注意药物的相互作用,以期更好地对患者进行个体化给药。
Objective: To study the effect of glucurolactone on plasma concentration of valproic acid in patients with epilepsy. Methods: From the perspective of drug interactions, explore the clinical analysis of 1 case of epilepsy patients taking glucurolactone plasma concentration of valproic acid concentration mechanism. Results: Combination therapy is one of the main factors affecting plasma concentration of valproic acid, glucurolactone may reduce plasma concentration of valproic acid, affecting its efficacy. Conclusion: When clinical treatment of epilepsy patients with combination therapy, should pay attention to drug interactions, in order to better individualized administration of patients.