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研究数据表明 ,金属离子反应可能是包括阿尔茨海默病、肌萎缩侧索硬化症、沅蛋白病、白内障、线粒体疾病以及帕金森病在内的众多疾病的共同发病基础 (公分母 ) ,在这些疾病中 ,某一种蛋白质与氧化还原反应金属离子之间产生的异常反应 ,促进了活性氧基团的形成。尤其是抗氧化剂 - Cu/Zn超氧化物歧化酶的强力催化氧化还原反应的活性 ,怎么能转化为促氧化活性。在最近的报道中 ,有一种观点引起了巨大的反响 ,即分别与阿尔茨海默病和沅蛋白病相关的 Aβ和 Pr P可能具有类似氧化还原反应的活性
The data suggest that the metal ion response may be the basis for common disease (common denominator) for many diseases, including Alzheimer’s disease, amyotrophic lateral sclerosis, galanses disease, cataract, mitochondrial disease and Parkinson’s disease, In these diseases, an abnormal reaction between a protein and a redox metal ion promotes the formation of reactive oxygen species. In particular, the antioxidant-Cu / Zn superoxide dismutase activity of the powerful catalytic oxidation and reduction reaction, how can be converted into pro-oxidative activity. In a recent report, one view elicited a huge response that Aβ and Pr P, which are associated with Alzheimer’s disease and Epstein-sickness respectively, may have similar redox-reactivity