目的:探讨丙酸睾酮注射液对脓毒症患者病情及预后的影响。方法:回顾性分析2009年6月至2019年10月渭南市中心医院重症医学科收治的61例脓毒症患者的临床资料，所有患者均给予抗感染、处理感染源、器官功能支持、加强营养等对症治疗。在常规治疗的基础上使用丙酸睾酮注射液100 mg深部肌肉注射每周2次（共2次）者作为观察组，未使用丙酸睾酮注射液者为对照组。观察两组患者一般资料及治疗前实验室指标，比较两组治疗后睾酮、白蛋白、急性生理学与慢性健康状况评分Ⅱ（APACHEⅡ）、序贯器官衰竭评分（SOFA）、重症监护病房（ICU）住院时间、住院总费用、机械通气时间、28 d全因病死率等指标。结果:两组性别、年龄等基线资料及治疗前实验室指标比较差异均无统计学意义。治疗后，观察组睾酮（μg/L：3.69±2.38比2.85±0.90）、白蛋白（g/L：39.87±1.98比26.25±4.13）均明显高于对照组，APACHEⅡ评分（分：13.71±2.13比23.23±2.52）、SOFA评分（分：4.45±1.57比9.97±2.65）、ICU住院时间（d：12.36±4.37比14.03±3.86）、住院总费用（万元：10.14±3.22比12.10±3.91）和机械通气时间（3.00±1.85比7.00±2.50）均明显低于对照组（均n P0.05〕。n 结论:丙酸睾酮注射液可以提高白蛋白水平，缩短机械通气时间，改善脓毒症患者的病情及预后。“,”Objective:To investigate the effect of testosterone propionate injection on the condition and prognosis of patients with sepsis.Methods:The clinical data of 61 sepsis patients admitted to the department of intensive care medicine, Weinan Central Hospital from June 2009 to October 2019 were retrospectively analyzed. All patients were treated with anti-infection, control of infection sources, organ function support, nutrition enhancement and supportive treatment. On the basis of routine treatment, observation group was given 100 mg of testosterone propionate injection for deep intramuscular injection twice a week (twice in total), and control group was not given testosterone propionate injection. The general information and laboratory indexes before treatment were observed, and the testosterone, albumin, acute physiology and chronic health evaluationⅡ(APACHEⅡ), sequential organ failure assessment (SOFA) score after treatment, intensive care unit (ICU) hospitalization time, total hospitalization cost, mechanical ventilation time, 28-day all-cause mortality and other indicators of the patients in two groups were compared.Results:There were no significant differences between the two groups in gender, age and other baseline data and laboratory indexes before treatment. After treatment, in observation group the testosterone (μg/L: 3.69±2.38 vs. 2.85±0.90) and albumin (g/L: 39.87±1.98 vs. 26.25±4.13) were significantly higher than those in control group. Total hospitalization expenses (ten thousand Yuan: 10.14±3.22 vs. 12.10±3.91), APACHEⅡ (13.71±2.13 vs. 23.23±2.52), SOFA (4.45±1.57 vs. 9.97±2.65), ICU hospitalization time (days: 12.36±4.37 vs. 14.03±3.86) and mechanical ventilation time (days: 3.00±1.85 vs. 7.00±2.50) were significantly lower than those in control group (alln P 0.05].n Conclusion:Testosterone propionate injection can increase albumin level, shorten the time of mechanical ventilation, and improve the condition and prognosis of patients with sepsis.