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目的探讨迷走神经阻滞对心房电重构的影响。方法对9只成年犬行高位右房快速刺激获得急性心房电重构模型,阿托品阻滞迷走神经,自身对照,测量阿托品阻断前、阿托品阻断后以及心房电重构后有和无迷走神经刺激下的有效不应期及房颤易感窗口。结果心房电重构后与重构前测得的有效不应期相比无统计学差异。应用阿托品前,迷走神经刺激容易诱发房颤;应用阿托品后,心房电重构前后无论有无迷走神经刺激均不能诱发房颤。结论迷走神经阻断剂阿托品能抑制心房电重构,抑制迷走神经介导性房颤。
Objective To investigate the effect of vagal block on atrial electrical remodeling. Methods Acute atrial electrical remodeling was performed in 9 adult dogs at high right atrium. Atropine blocks the vagus nerve and self-control, and before and after atropine blockade, atropine blockade, and atrial electrical remodeling with and without vagal nerve stimulation Effective refractory period and atrial fibrillation susceptibility window. Results There was no significant difference between the atrial electrical remodeling and the effective refractory period measured before reconstruction. Before the application of atropine, vagus nerve stimulation easily induce atrial fibrillation; atropine, before and after atrial electrical remodeling with or without vagus nerve stimulation can not induce atrial fibrillation. Conclusions Atropine, a vagal blocker, can inhibit atrial electrical remodeling and inhibit vagal-mediated atrial fibrillation.