近年来,对洋地黄的代谢、药代动力学及电生理效应等有了进一步认识,地高辛维持量疗法取代了传统的洋地黄饱合疗法。虽然中毒发生率15～20%及病死率3～21%有明显下降,但仍有5.7～11.3%的患者中毒,一旦中毒发生,病死率可达5～10%。现将笔者遇到的28例维持量地高辛中毒报告如下,并略加分析。 In recent years, further understanding of digitalis metabolism, pharmacokinetics and electrophysiological effects, digoxin maintenance dose therapy to replace the traditional digitalis satiety therapy. Although the incidence of poisoning 15 ~ 20% and mortality 3 ~ 21% decreased significantly, but there are still 5.7 ~ 11.3% of patients poisoning, once poisoning, fatality rate of up to 5 to 10%. Now I encountered 28 cases of maintenance digoxin poisoning reported as follows, and a little analysis.