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目的 :探讨卵巢癌患者心理健康状况及其对机体细胞免疫的影响。方法 :采用 90项症状清单、焦虑自评量表及抑郁自评量表 ,对 52例卵巢癌患者及 50例卵巢良性肿瘤患者进行了心理健康状况测评。所有卵巢癌患者均采用流式细胞法检测了其外周血T细胞亚群及NK细胞活性。结果 :与卵巢良性肿瘤组相比 ,卵巢癌患者精神症状多、焦虑及抑郁程度重 ,伴有中、重度抑郁及焦虑的患者其外周血CD8细胞百分比明显增高、CD4 /CD8值降低、NK细胞活性低下。结论 :大部分卵巢癌患者存在不同程度的精神症状。中、重度的抑郁及焦虑可导致机体细胞免疫功能下降。在对卵巢癌患者进行躯体治疗的同时 ,有必要同时提供心理治疗干预
Objective: To investigate the mental health of patients with ovarian cancer and its impact on cellular immunity. Methods: Fifty-two patients with ovarian cancer and 50 patients with benign ovarian tumor were evaluated for their mental health status using 90 symptom checklist, anxiety self-rating scale and depression self-rating scale. All ovarian cancer patients were detected by flow cytometry T lymphocyte subsets and NK cell activity. Results: Compared with the benign ovarian tumor group, patients with ovarian cancer had more psychiatric symptoms, severe anxiety and depression, and the percentage of CD8 cells in peripheral blood and CD4 / CD8 decreased in moderate and severe depression and anxiety patients. NK cells Low activity. Conclusion: Most ovarian cancer patients have different degrees of mental symptoms. Moderate and severe depression and anxiety can lead to cellular immune function decline. While somatic treatment of ovarian cancer patients, it is necessary to provide psychotherapy intervention