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目的 :探索 5 HT1D受体在偏头痛发病中的中枢角色。方法 :应用大鼠电刺激偏头痛模型 ,观察给予佐米曲普坦和BRL15 5 72后三叉神经脊束核尾段和上颈髓背角的c fos表达变化。结果 :佐米曲普坦明显抑制电刺激诱发的三叉神经脊束核尾段和上颈髓背角浅层神经元c fos表达 ,BRL15 5 72可拮抗佐米曲普坦的大部分抑制效应 ,单独BRL15 5 72对c fos表达无影响。结论 :5 HT1D受体在偏头痛模型中是调节三叉神经二级神经元兴奋的主要受体 ,曲坦类药物通过 5 HT1D受体抑制该神经元伤害性兴奋。
Objective: To explore the central role of 5 HT1D receptors in the pathogenesis of migraine. Methods: The rat model of electrical stimulation of migraine was used to observe the changes of c fos expression in caudal and supraspinal medulla dorsal horn after the administration of zolmitriptan and BRL15 5 72. RESULTS: Zolmitriptan significantly inhibited the c fos expression in the caudal and supraspinal spinal dorsal horn neurons induced by electrical stimulation. BRL15 5 72 antagonized most inhibitory effects of zolmitrate, BRL 15 5 72 alone had no effect on c fos expression. CONCLUSIONS: 5 HT1D receptors are the major receptors that regulate the excitability of secondary neurons in trigeminal neuralgia in the migraine model. Triptans inhibit this neuronal noxious stimulation through the 5HT1D receptor.