曲安奈德治疗重度糖尿病黄斑水肿的临床观察

来源 :中国实用医药 | 被引量 : 0次 | 上传用户:xinxi_2009
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
目的研究玻璃体腔内注射曲安奈德(TA)治疗重度糖尿病黄斑水肿的有效性。方法对36例(42眼)重度糖尿病黄斑水肿的患者,行玻璃体腔内注射TA(进口)(4mg/0.1ml)的治疗方法。观察治疗前后的四个指标:最佳矫正视力、眼压、眼底荧光血管造影(FFA)、OCT检测黄斑中心凹厚度。随访时间6~12个月(平均9个月)。结果本组病例36例(42眼),年龄45~70岁(平均57岁),FFA检查治疗前黄斑荧光渗漏明显,治疗后渗漏明显减轻;OCT检测黄斑中心凹厚度,治疗前平均(579.5±65)μm,治疗随访6个月后平均(279±78)μm,差异有统计学意义(P<0.05);最佳矫正视力范围治疗前为0.01~0.2,平均0.1,治疗后为0.2~0.4,平均0.3,差异有统计学意义(P>0.05);所有患者眼压都有升高,升高值8.0~20.0mmHg(平均14.0mmHg),7例(7眼)超过正常眼压范围,经治疗,眼压控制,没有严重并发症发生。结论玻璃体腔注射TA是治疗重度糖尿病黄斑水肿的有效方法,患者的视力有轻度提高,治疗后患者FFA,黄斑区荧光素渗漏明显减轻,OCT检查,证实黄斑厚度明显减小。 Objective To study the efficacy of intravitreous injection of triamcinolone acetonide (TA) in the treatment of severe diabetic macular edema. Methods Thirty-six patients (42 eyes) with severe diabetic macular edema were treated with intravitreal injection of TA (4mg / 0.1ml). Four indicators before and after treatment were observed: best corrected visual acuity, intraocular pressure, fundus fluorescein angiography (FFA) and OCT for macular foveal thickness. Follow-up time of 6 to 12 months (mean 9 months). Results The group of 36 patients (42 eyes), aged 45 to 70 years (mean 57 years), FFA before treatment macular fluorescence leakage significantly reduced leakage after treatment; OCT detection foveal thickness, average ( 579.5 ± 65) μm, and the mean follow-up was (279 ± 78) μm after 6 months of follow-up. The difference was statistically significant (P0.05) .The best corrected visual acuity range was 0.01-0.2 before treatment, ~ 0.4, an average of 0.3, the difference was statistically significant (P> 0.05); all patients had elevated intraocular pressure, elevated 8.0 ~ 20.0mmHg (average 14.0mmHg), 7 cases , After treatment, intraocular pressure control, no serious complications. Conclusion Intravitreal injection of TA is an effective method for the treatment of severe diabetic macular edema. The visual acuity of patients with mild diabetic macular edema is slightly increased. Fluorescein leakage in FFA and macula is significantly reduced after treatment. The thickness of macula is significantly reduced by OCT.
其他文献
期刊
5-硝基水杨醛与氯乙基吡咯烷盐酸盐经亲核取代得到5-硝基-2-[2-(吡咯烷-1-基)乙氧基]苯甲醛,然后经醛基还原、取代、硝基还原及成盐得到3-[(烯丙氧基)甲基]-4-[2-(吡咯烷-1-
目的 探讨胆囊切除术后胆流动力学改变与大肠癌发病关系及机制.方法 将130例胆道结石手术患者随机分为对照组65例(胆囊切除术胆总管探查术);观察组65例(胆总管切开取石术),采
期刊
雷帕霉素与2-[(四氢-2H-吡喃-2-基)氧基]乙基三氟甲磺酸酯在有机碱作用下缩合得到40-O-[(四氢-2H-吡喃-2-氧基)乙基]雷帕霉素,然后直接在酸性条件下脱除缩醛保护基,最后经制
介绍1种用单片机发出脉冲信号来实现直流电动机调速控制的方法,此系统具有器件功率大、体积小、控制灵活、简单、损耗低、效率高等特点。 This paper introduces a method o
文章阐述了新型电动机综合保护器JRD2 2型的产品原理 ,设计特点 ,介绍了其试验及符合标准。 The paper expounds the product principle and design features of JRD2 2 typ
本文针对矿井综合监控系统的需求 ,研究了矿用组态软件中最具普遍意义的功能模块的设计方法。 In this paper, according to the demand of mine comprehensive monitoring
期刊
期刊