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本实验用卵巢癌腹水提纯的免疫抑制性酸性蛋白(IAP)制备的单克隆抗体MI_1和MI_2,对33例卵巢上皮性癌进行免疫组化研究,结果表明,两株抗体的阳性着染率与卵巢癌的类型及病理分级关系不显著,但通过临床随访发现阳性着染程度似与临床分期及预后密切相关。这对于临床上判断预后、估计复发及指导治疗等有一定的意义。此外,MI_2识别的I AP的亚型,似主要由癌细胞产生,考虑有可能作为诊断卵巢癌的一种标志物。
In this study, monoclonal antibodies Ml_1 and Ml_2, prepared from immunosuppressive acidic protein (IAP) purified from ascites of ovarian cancer, were used to study the immunohistochemistry of 33 cases of epithelial ovarian cancer. The results showed that the positive staining rates of two antibodies Ovarian cancer type and pathological grade relationship was not significant, but found by clinical follow-up positive staining level and clinical stage and prognosis are closely related. This is clinically determine the prognosis, the estimated recurrence and guiding treatment has a certain significance. In addition, the subtype of IAP identified by MI_2 seems to be mainly produced by cancer cells, which may be considered as a marker for the diagnosis of ovarian cancer.