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目的：评价国产香菇多糖在增强免疫及肿瘤治疗方面的作用。方法：采用随机双盲法，将４２例恶性肿瘤病人（男性３４例，女性８例，平均年龄５６±ｓ１３ａ）分为２组：Ａ组２０例，用化学治疗加香菇多糖１ｍｇ，２次／ｗｋ，６￣８ｗｋ为一个疗程；Ｂ组２２例仅用化学治疗，对２组治疗效果及免疫功能进行比较。结果：治疗后Ａ组天然杀伤细胞（ＮＫ细胞）活性、Ｔ细胞亚群中Ｔ４／Ｔ８比值明显高于Ｂ组，Ａ组有效率６０％，明显高于Ｂ组的有效率３２％，Ｐ＜０．０５。２组毒副作用相似。结论：应用香菇多糖可提高恶性肿瘤病人细胞免疫功能及化学治疗效果。
Objective: To evaluate the role of domestic lentinan in enhancing immunity and tumor treatment. METHODS: 42 patients with malignant tumors (34 males and 8 females, mean age 56 ± s13a) were divided into 2 groups by randomized double-blind method: 20 patients in group A were treated with chemical therapy plus lentinan 1 mg twice daily. Wk, 6 ~ 8wk for a course of treatment; B group of 22 cases with only chemotherapy, the treatment of two groups and comparison of immune function. Results: After treatment, the natural killer cell (NK cell) activity in group A and the T4/T8 ratio in T cell subsets were significantly higher than those in group B. The effective rate in group A was 60%, which was significantly higher than that in group B (32%). P< 0.05. 2 groups of toxic side effects. Conclusion: The application of lentinan can improve the cellular immune function and chemotherapy effect of malignant tumor patients.