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本文观察了国产抗心血管疾病新药氨利酮在V_(79)细胞HGPRT位点（hgpoxanthine-guanine phos-phoribosyl transferase locus，次黄嘌呤鸟嘌呤转磷酸核糖基酸位点）正向突变试验系统中的诱变作用。结果表明：氟利酮在-S9情况下，各浓度组突变体频率（mutant frequency、MF）与对照组相比均未达到MF≥3SMF的标准，也无剂量反应关系；但相同浓度在+S9情况下，除高浓度组（200μg/ml）外，其余三组MF随浓度增加而升高，且次高浓度组（100μg/ml）MF是对照组的3.8倍，故在本试验条件下氨利硐是需活化的诱变剂。
In this paper, we observed that in the forward mutation test system of domestic anti-cardiovascular drug amincuronatine in the HgPRT site of V_ (79) cells (hgpoxanthine-guanine phos-phoribosyl transferase locus) The mutagenic effect. The results showed that in the condition of -S9, the mutant frequency (MF) of each concentration group did not reach the standard of MF≥3SMF, nor the dose-response relationship; however, the same concentration was found between + S9 In addition to the high concentration group (200μg / ml), the other three MF group increased with increasing concentration, and the second high concentration group (100μg / ml) MF was 3.8 times the control group, so under the conditions of this test ammonia Lee cave is a need to activate the mutagen.