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目的 探讨心钠肽 (ANP)基因C/T多态性与2型糖尿病视网膜病变间是否存在关联 ,评估其在2型糖尿病视网膜病变遗传易感性中的可能作用。方法 运用聚合酶链反应 -限制性片段长度多态性分析技术在78例2型糖尿病患者 (包括40例2型糖尿病无视网膜病变患者和38例2型糖尿病视网膜病变患者 )和40名正常对照者中对ANP基因C/T多态性进行检测。结果 ANP基因型及等位基因频率分布在2型糖尿病视网膜病变组较2型糖尿病无视网膜病变组、正常对照组均无显著性差异。结论 在中国汉族人的2型糖尿病患者中 ,ANP基因C/T多态性与2型糖尿病视网膜病变的发生可能不相关 ,即该多态性可能不是2型糖尿病发生视网膜病变的主要遗传标志
Objective To investigate whether ANP gene C / T polymorphism is associated with type 2 diabetic retinopathy and to evaluate its possible role in the genetic susceptibility to type 2 diabetic retinopathy. Methods The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used in 78 patients with type 2 diabetes mellitus (including 40 patients with type 2 diabetes without retinopathy and 38 patients with type 2 diabetes mellitus) and 40 normal controls In the ANP gene C / T polymorphism were detected. Results ANP genotype and allele frequency distribution in type 2 diabetic retinopathy group than in type 2 diabetic retinopathy group, normal control group no significant difference. Conclusions In Chinese Han patients with type 2 diabetes mellitus, ANP C / T polymorphism may not be associated with type 2 diabetic retinopathy, indicating that this polymorphism may not be the major genetic marker of type 2 diabetic retinopathy