目的分析晚期肝硬化合并真菌感染的临床特点和治疗方法。方法采用回顾性调查方法对30例晚期肝硬化合并真菌感染患者的临床资料以及相关因素进行整体分析。结果 30例患者中,病发真菌感染以深部感染为主,其中,感染部位以肠道为主,占50.4%;其次是口腔感染,占12.3%、下呼吸道占16.2%,腹腔占8.2%、泌尿道占7.9%和血液占5.0%;感染菌种主要以曲霉菌及白色念珠菌为主;在30例晚期肝硬化合并真菌感染的患者中,85%的患者有侵袭性操作、广谱抗生素以及各种免疫剂的使用。30例患者中,合并医院真菌感染者中死亡的25例,占83.3%,与真菌直接相关的有3例,使用抗生素的效果相对较差,预后不良而且病死率也比较高。结论晚期肝硬化合并真菌感染预后差,病死率相对较高,应该采取多种综合措施,积极预防,加强护理措施的运用。 Objective To analyze the clinical features and treatment of advanced liver cirrhosis complicated with fungal infection. Methods A retrospective investigation was performed on the clinical data and related factors of 30 patients with advanced cirrhosis and fungal infection. Results Among the 30 patients, the main pathogenic fungal infection was deep infection, of which the predominant intestinal part was 50.4%, followed by oral infection (12.3%), lower respiratory tract (16.2%), abdominal cavity (8.2%), Urinary tract accounted for 7.9% and blood accounted for 5.0%; Infected strains are mainly Aspergillus and Candida albicans; in 30 cases of patients with advanced cirrhosis and fungal infection, 85% of patients have aggressive operation, broad-spectrum antibiotics As well as the use of various immunological agents. Among the 30 patients, 25 cases died of fungal infection in the hospital, accounting for 83.3%. There were 3 cases directly related to fungi. The antibiotic effect was relatively poor, the prognosis was poor and the case fatality rate was relatively high. Conclusions The prognosis of advanced cirrhosis complicated with fungal infection is poor and the mortality rate is relatively high. A variety of comprehensive measures should be taken to prevent and enhance the application of nursing measures.