移植物增加表达ＭＨＣ抗原，尤其是Ⅱ类抗原分子，是移植排斥反应的起点。血管内皮细胞不恰当地表达ＭＨＣⅡ类抗原被认为是许多疾病过程如炎症、血栓形成、血管炎的焦点。研究发现冠脉内皮细胞常规表达ＭＨＣⅡ类抗原存在种属间的差异，而这种差异或许是导致不同动物模型间出现实验（主要指免疫学实验）结果差异的关键因素。 Grafts increase the expression of MHC antigens, especially class II antigen molecules, is the starting point of graft rejection. Inappropriate expression of MHC class II antigens by vascular endothelial cells is considered to be the focus of many disease processes such as inflammation, thrombosis, and vasculitis. The study found that there are interspecific differences in the routine expression of MHC class II antigens in coronary endothelial cells, and this difference may be the key factor leading to differences in the results of experiments (mainly immunological experiments) between different animal models.