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目的 :观察亚硒酸钠、大蒜素及其合并用药对糖尿病小鼠心脏抗氧化功能及血液成分改变的保护作用。方法 :以四氧嘧啶糖尿病小鼠动物模型 ,测定心脏抗氧化酶、脂质过氧化产物、一氧化氮 (NO)和血液成份的含量。结果 :糖尿病小鼠心脏抗氧化功能明显下降 ,NO含量明显减少 ,血液中白细胞数及血红蛋白含量明显下降 ,胆固醇含量明显升高 ;与糖尿病模型组小鼠相比 ,硒、大蒜素能明显逆转上述变化 ,其中硒对谷胱甘肽过氧化物酶(GSHpx)活性的作用强于大蒜素 ,大蒜素对 SOD活性的影响较大 ;硒、大蒜素合并用药较单独作用减弱。结论 :硒、大蒜素对糖尿病小鼠心脏及血液成分具有良好的保护作用 ,两药合用作用减弱。结论 :提示临床用药应注意药物的相互作用
Objective: To observe the protective effects of sodium selenite, allicin and their combination on the anti-oxidative function and blood components in diabetic hearts. Methods: The animal models of alloxan diabetic mice were used to determine the contents of cardiac antioxidant enzymes, lipid peroxidation products, nitric oxide (NO) and blood components. Results: The anti-oxidant function of diabetic mice significantly decreased, the content of NO significantly decreased, the number of blood leukocytes and hemoglobin decreased significantly, and the content of cholesterol increased significantly. Compared with diabetic model mice, selenium and allicin significantly reversed the above The effect of selenium on glutathione peroxidase (GSHpx) activity was stronger than that of allicin. Allicin had a significant effect on SOD activity. The combination of selenium and allicin reduced the effect of GSHpx alone. Conclusion: Selenium and allicin have a good protective effect on the heart and blood components of diabetic mice, and their combined effects are weakened. Conclusion: It is suggested that drug interactions should be noticed in clinical medication