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1例36岁女性患者,因患甲状腺机能亢进症给予甲巯咪唑10 mg,3次/d,普萘洛尔10 mg,3次/d治疗。服药23 d后,患者出现皮疹、食欲下降和恶心。实验室检查示:WBC 1.6×109/L,中性粒细胞绝对值0.80×109/L;ALT125.0 U/L,AST62.0 U/L。停用甲巯咪唑,给予还原型谷胱甘肽、水飞蓟宾、氯雷他定及非格司亭治疗后好转。患者WBC为4.30×109/L,中性粒细胞绝对值为3.1×109/L,ALT和AST分别为27.0 U/L和17.0 U/L。
One 36-year-old female patient was treated with 10 mg of methimazole, 3 times daily, and propranolol 10 mg thrice daily for hyperthyroidism. After taking medication for 23 days, the patient developed a rash, loss of appetite and nausea. Laboratory tests showed: WBC 1.6 × 109 / L, absolute neutrophil 0.80 × 109 / L; ALT125.0 U / L, AST62.0 U / L. Methimazole was discontinued, and glutathione, silibinin, loratadine and filgrastim were also improved after treatment. The WBC was 4.30 × 109 / L, the absolute neutrophil count was 3.1 × 109 / L, ALT and AST were 27.0 U / L and 17.0 U / L, respectively.