本文对吸入750mg/m~3CO大鼠血COHb及主动脉内膜形态学改变进行了观察。结果:大鼠血COHb显著增高,主动脉内膜细胞结构未见改变,超微结构出现胞浆疏松,胶原纤维增生等改变,并随染毒时间延长,内皮细胞间隙增大、断裂,内皮细胞核扭曲、变形,细胞器崩解,内膜破损。表明:接触CO引起主动脉内膜超微结构改变,在CO所致动脉粥样硬化病因学中有重要意义。 In this paper, 750 mg / m ~ 3CO inhalation of blood COHb and aortic endometrial morphological changes were observed. Results: The COHb in the blood of rats was significantly increased, the structure of aorta intima was not changed, the ultrastructure of the aorta showed the changes of cytoplasm looseness and collagen fiber hyperplasia. With the prolongation of exposure time, the endothelial cell gap increased and the endothelial cell nucleus Distortion, deformation, organelles disintegration, intimal damage. It is indicated that exposure to CO causes changes in the intima ultrastructure of the aorta and is of great importance in the etiology of atherosclerosis induced by CO.