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AIM:To investigate T helper 17/regulatory T cell alterations in early severe hepatitis B and the effect of glucocorticoids.METHODS:The study included 20 patients in the early stage of severe hepatitis B(SHB)and 11 healthy controls.All patients had elevated T helper 17(Th17)levels,decreased regulatory T(Treg)cell levels,and significant Th17/Treg ratios.RESULTS:After glucocorticoid treatment,16 patients showed improvement with significant decreases in Th17 levels,increases in Treg,and rebalanced Th17/Treg ratios.The four patients who showed no improvement had increases in both Th17 and Treg levels andan even higher Th17/Treg ratio than before.CONCLUSION:Glucocorticoid treatment can rectify Th17/Treg dysregulation in patients with SHB.
AIM: To investigate T helper 17 / regulatory T cell alterations in early severe hepatitis B and the effect of glucocorticoids. METHODS: The study included 20 patients in the early stage of severe hepatitis B (SHB) and 11 healthy controls. All patients had elevated Tregs and Th17 / Tregs were significantly decreased in Th17 levels, increased in Tregs, and rebalanced Th17 levels ratios. the four patients who showed no improvement had increases in both Th17 and Treg levels and even even Th17 / Treg ratios than before.CONCLUSION: Glucocorticoid treatment can rectify Th17 / Treg dysregulation in patients with SHB.