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目的:探讨基于社区人群的中老年男性血清生殖激素及同型半胱氨酸(Hcy)水平与代谢综合征(MS)及其组分之间的相互关系。方法:以农村社区人口为基础,采用整群及年龄分层抽样相结合的方法,调查中老年男性948例。采用统一的结构式问卷进行调查,测量其基本身体参数,检测其血清生殖激素、Hcy浓度和代谢指标。本研究共获得有效问卷与血清样本868份。将研究对象按照是否患有MS,划分成MS组和非MS(NMS)组,并且按照1∶1设立对照组测定其血清Hcy浓度进行研究。结果:132例诊断为MS。经非参数检验,两组间年龄无统计学差异(P>0.05),腰围(WC)、腰臀比(WHR)、体质指数(BMI)、收缩压(SBP)、舒张压(DBP)均有显著性差异(P均<0.05)。两组间实验室参数进行比较,其中总睾酮(t T)、性激素结合球蛋白(SHBG)、黄体生成素(LH)和游离睾酮指数(FTI)均有显著差异(P均<0.05),但Hcy浓度无统计学差异(P>0.05)。Hcy与MS危险因素的关联研究中,Hcy与BMI、SBP、DBP、FBG、TG、HDL-C均无相关性(P均>0.05)。MS相关因素的Logistic回归分析显示Hcy对MS无显著影响。结论:血清Hcy与MS未见显著相关性,与MS各个组分也未见显著相关性。男性血清生殖激素与MS及其各个组分存在不同程度的显著相关性。
Objective: To investigate the relationship between serum reproductive hormones and homocysteine (Hcy) levels and metabolic syndrome (MS) and their components in middle-aged and elderly men in community-based population. Methods: Based on the population of rural communities, a total of 948 middle-aged and elderly men were investigated using a combination of cluster sampling and stratified age stratification. A uniform structural questionnaire was used to investigate and measure the basic body parameters and to detect serum reproductive hormones, Hcy concentration and metabolic parameters. A total of 868 valid questionnaires and serum samples were obtained in this study. Subjects were divided into MS group and non-MS (NMS) group according to whether they had MS or not, and their serum Hcy concentration was determined according to 1: 1 control group. Results: 132 cases were diagnosed as MS. The results of nonparametric test showed that there was no significant difference between the two groups in age (P> 0.05), waist circumference (WH), body mass index (BMI), systolic blood pressure (SBP) and diastolic blood pressure Significant difference (P <0.05). There were significant differences in total testosterone (t T), sex hormone-binding globulin (SHBG), luteinizing hormone (LH) and free testosterone index (FTI) between the two groups Hcy concentration was no significant difference (P> 0.05). Hcy and MS risk factors in the study, Hcy and BMI, SBP, DBP, FBG, TG, HDL-C were no correlation (P all> 0.05). Logistic regression analysis of MS-related factors showed no significant effect of Hcy on MS. Conclusion: There is no significant correlation between serum Hcy and MS, and no significant correlation with the various components of MS. Serum reproductive hormones with MS and its various components exist to varying degrees of significant correlation.