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The sphingosine 1-phosphate receptor 2(S1PR2),along with insulin,plays an important role in the regulation of nutrient metabolism in the liver.Following a meal,conjugated bile acids(CBAs)returning to the liver bind to S1PR2 activating both the ERK1/2 and AKT(insulin signaling pathway).Activation of the insulin signaling pathway by
The sphingosine 1-phosphate receptor 2 (S1PR2), along with insulin, plays an important role in the regulation of nutrient metabolism in the liver. Flowing a meal, conjugated bile acids (CBAs) returning to the liver bind to S1PR2 activating both the ERK1 / 2 and AKT (insulin signaling pathway). Activation of the insulin signaling pathway by