论文部分内容阅读
目的 :研究神经心理学测验和脑SPECT对帕金森病(PD)的诊断价值。材料和方法 :对30例正常老人(NA)和31例PD进行神经心理学测验(MMSE ,FOM ,DST ,RVR ,BD)和SPECT检查 ,比较两组认知功能和脑血流灌注特点。结果 :两组间各测验(MMSE ,FOM ,DST ,RVR ,BD)结果均有显著差异 ,NA各测验得分均高于PD。与NA相比 ,PD双侧顶叶、颞叶、基底节、丘脑的放射性计数比值显著降低(P<0.05)。相关和回归分析提示PD患者脑SPECT放射性计数值比值与神经心理学测验结果有一定关系 ,FOM分数与顶叶、左颞叶、左丘脑分别有显著性相关(P<0.05) ,提示可用FOM间接反映上述区域脑血流灌注情况。结论 :神经心理学测验和脑SPECT可作为诊断PD的辅助手段。
Objective: To study the diagnostic value of neuropsychological test and brain SPECT in Parkinson’s disease (PD). MATERIAL AND METHODS: Neuropsychological tests (MMSE, FOM, DST, RVR, BD) and SPECT were performed in 30 normal controls and 31 PD patients. The cognitive function and cerebral perfusion were compared between the two groups. Results: There were significant differences between the two groups in the test results (MMSE, FOM, DST, RVR, BD), NA test scores were higher than the PD. Compared with NA, the ratio of radioactivity in PD bilateral parietal lobe, temporal lobe, basal ganglia and thalamus was significantly decreased (P <0.05). Correlation and regression analysis indicated that the ratio of brain SPECT radioactivity in PD patients was correlated with neuropsychological test results. There was a significant correlation between FOM score and parietal lobe, left temporal lobe, and left thalamus (P <0.05) Reflect the above regional cerebral perfusion. Conclusion: Neuropsychological tests and brain SPECT can be used as an adjunct to diagnosing PD.