AIM: To explore the regularity of multi-meridians controlling a same viscus (MMCSV).METHODS: The rabbit gastric ulcer model was established by ethanol intragastric instillation. Fifty-six rabbits were randomly divided into normal group, model group (MG), model plus acupuncture at Foot Yangming Meridian group (YMG), model plus acupuncture at Foot Taiyin Meridian group (TYG), model plus acupuncture at Foot Shaoyang Meridian group (SYG), model plus acupuncture at Foot Jueyin Meridian group (JYG), model plus acupuncture at Foot Taiyang Meridian group (TYMG),with eight rabbits in each group. Gastric mucosal nitric oxide (NO) and nitric oxide synthase (NOS) were assayed by the nitric acid reductase method, and prostaglandin E2 (PGE2) and epidermal growth factor (EGF) were measured by radioimmunoassay. The comprehensive effects were analyzed by weighing method.RESULTS: Compared to MG, SYG, JYG and TYMG, the rabbits gastric mucosal injury index (GMⅡ) reduced very significantly in YMG (P＜0.01). Compared to MG, the GMⅡ also reduced significantly in TYG (P＜0.05). NO,NOS, PGE2 and EGF increased very significantly in YMG (P＜0.01). The EGF in YMG also increased significantly than that in TYG compared to those in MG, SYG, JYG and TYMG (P＜0.05). The PGE2 and EGF also increased very significantly in TYG than those in MG, JYG and TYMG (P＜0.01). While compared to SYG, the NOS increased significantly in TYG (P＜0.05). NOS was thehighest in YMG (P＜0.01), and was higher in TYG than in MG (P＜0.01).CONCLUSION: MMCSV is common. The Foot Yangming Meridian is most closely related to the stomach, followed by Foot Taiyin Meridian, Foot Shaoyang Meridian and Foot Jueyin Meridian. Foot Taiyang Meridian has no correlation with the stomach.