论文部分内容阅读
目的:探讨静脉滴注2种剂量丙种球蛋白(IVIG)治疗新生儿ABO溶血病(ABO HDN)的疗效。方法:将ABO HDN患儿随机分成两组,A组为对照组,IVIG 0.5 g/(kg.d),单次静滴;B组为治疗组,IVIG 1.0 g/(kg.d),单次静滴。观察两组黄疸消退时间,24 h、48 h血清胆红素值(BT)及血红蛋白值(Hb)。结果:B组黄疸消退时间较A组缩短(t=2.27,P<0.05),24 h血清胆红素较A组低(t=4.81,P<0.05),48 h血清胆红素与A组有显著差异(t=2.21,P<0.05),24 h Hb(t=4.24,P<0.05)、48 h Hb(t=3.46,P<0.05)较A组高。结论:治疗新生儿ABO溶血病应用大剂量IVIG〔1 g/(kg.d)〕获取较好的临床疗效。
Objective: To investigate the efficacy of intravenous infusion of two doses of gamma globulin (IVIG) in neonatal ABO hemolytic disease (ABO HDN). Methods: The children with ABO HDN were randomly divided into two groups. Group A was control group, IVIG 0.5 g / (kg · d), single intravenous infusion. Group B was treated with IVIG 1.0 g / (kg · d) Intravenous infusion The jaundice extinction time, serum bilirubin (BT) and hemoglobin (Hb) value of 24 h and 48 h were observed. Results: The regression time of jaundice in group B was shorter than that in group A (t = 2.27, P <0.05), serum bilirubin in group B was lower than that in group A (t = 4.81, P <0.05) (T = 2.21, P <0.05), 24 h Hb (t = 4.24, P <0.05) and 48 h Hb (t = 3.46, P <0.05) Conclusion: The treatment of neonatal ABO hemolytic disease with high-dose IVIG 〔1 g / (kg · d)〕 to obtain a better clinical effect.