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目的探讨频域三维相干光学断层扫描(3D-OCT)测量中央角膜厚度(CCT)的准确性及可重复性。方法分别用3D-OCT、Orbscan-Ⅱ及超声角膜测厚仪测量近视患者265例(530眼)的CCT,对测量结果进行随机分组设计的方差分析及LSD检验,通过对三者测量值间差异检验3D-OCT测量CCT的准确性;用相关分析方法分析三者间相关性;并同时随机选取50例(100眼)近视患者用3D-OCT重复测量3次用类内相关系数(ICCs)检验可重复性。结果 3D-OCT、Orbscan-Ⅱ及超声角膜测厚仪测得的CCT均值分别为(538.78±23.83)μm、(537.51±39.15)μm、(554.09±37.31)μm。3D-OCT与Orbscan-Ⅱ测量CCT值间差异无统计学意义(P=0.245),两者均小于超声角膜测厚仪测得的CCT值,且差异有统计学意义(P值均<0.001)。3D-OCT、Orbscan-Ⅱ及超声角膜测厚仪三种仪器测量CCT值间有良好的相关性(r1,2=0.866、r2,3=0.806、r1,3=0.800,均P<0.001),并且3D-OCT具有很好的可重复性(ICCs=0.905)。结论由于3D-OCT对CCT测量与超声角膜测厚仪测量值之间较好的相关性及测量值的可重复性,因此可以将3D-OCT作为临床上一种非接触式CCT的测量方法。
Objective To investigate the accuracy and repeatability of central corneal thickness (CCT) measured by 3D-OCT in frequency domain. Methods The CCT of 265 cases (530 eyes) of myopia were measured by 3D-OCT, Orbscan-Ⅱ and echocardiography respectively. The results of variance were analyzed by randomisation and LSD. The differences between the three measurements OCT was used to test the accuracy of CCT. Correlation analysis was used to analyze the correlation between the three. At the same time, 50 cases (100 eyes) of myopia were randomly selected and tested by 3D-OCT repeatedly with ICCs Repeatability. Results The CCT values measured by 3D-OCT, Orbscan-Ⅱ and echocardiography were 538.78 ± 23.83 μm, 537.51 ± 39.15 μm and 554.09 ± 37.31 μm, respectively. There was no significant difference between 3D-OCT and Orbscan-Ⅱ in CCT (P = 0.245), both of which were lower than CCT values measured by echocardiography, and the difference was statistically significant (P <0.001) . There was a good correlation between CCT values measured by 3D-OCT, Orbscan-Ⅱ and echocardiography (r1,2 = 0.866, r2,3 = 0.806, r1,3 = 0.800, all P <0.001) And 3D-OCT has good repeatability (ICCs = 0.905). Conclusions 3D-OCT can be used as a clinically noncontact CCT measurement due to the good correlation between the CCT measurements and the echocardiographic measurements and the repeatability of the measurements.