混合冷沉淀球蛋白血症为一系列免疫紊乱,其特征为病人血清中出现IgG-IgM冷沉淀球蛋白。这种冷沉淀免疫复合物具有类风湿因子活性及低溶血补体活性。弥漫性脉管炎为典型的组织学改变,随之冷沉淀免疫复合物分解。慢性肝炎、周围神经病、肾小球肾炎为本病最常见的内脏并发病。抗丙型肝炎病毒(HCV)抗体和混合冷沉淀球蛋白血症之间有密切的关系,通常伴有HCV血症,因此有人提示在混合冷沉淀球蛋白血症中HCV可能具有主要的病原作用。 Mixed cryoprecipitin is a series of immune disorders characterized by the presence of IgG-IgM cryoprecipiens in the patient’s serum. This cryoprecipitate immune complex has rheumatoid factor activity and low hemolysis complement activity. Diffuse vasculitis is a typical histological change, followed by cryoprecipitation immune complex decomposition. Chronic hepatitis, peripheral neuropathy, glomerulonephritis-based disease of the most common internal organs and disease. There is a close relationship between anti-hepatitis C virus (HCV) antibodies and mixed crymucinemia, often associated with HCV blood transfusions, so it has been suggested that HCV may have a major etiologic role in mixed cryoprecipitin .