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目的:观察复方丹参冻干粉针对异丙肾上腺素(ISO)所致大鼠急性心肌缺血的保护作用。方法:采用scISO复制大鼠急性心肌缺血模型,观察给予复方丹参冻干粉针5d后大鼠血清中磷酸肌酸激酶(CK)、乳酸脱氢酶(LDH)和超氧化物歧化酶(SOD)、丙二醛(MDA)含量的变化。结果:复方丹参冻干粉针与复方丹参注射液均能明显提高大鼠血清中SOD活性,降低CK,LDH,MDA含量,两给药组之间的LDH,SOD,MDA值比较,也有统计学意义。结论:复方丹参冻干粉针对改善心肌酶学指标的作用优于复方丹参注射液。
Objective: To observe the protective effect of Fufang Danshen freeze-dried powder against acute myocardial ischemia induced by isoproterenol (ISO) in rats. Methods: A rat model of acute myocardial ischemia was induced by scISO. Serum levels of CK, LDH and SOD in serum of SD rats treated with Fufang Danshen freeze-dried powder for 5 days were observed. ), Malondialdehyde (MDA) content changes. Results: Both the Danshen freeze-dried powder injection and compound Salvia miltiorrhiza injection could significantly increase the activity of SOD in serum and decrease the content of CK, LDH and MDA in the serum of rats, and the LDH, SOD and MDA between the two groups were also statistically significant significance. Conclusion: The effect of Fufang Danshen freeze-dried powder on improving myocardial enzymology index is better than Fufang Danshen injection.