在过去的十年中,关于多肽激素及其细胞膜上的受体的结构和功能的研究已取得了长足的进展,而在细胞的恒稳机制中起作用的有关内源性细胞生长抑制因子的研究却进展不大。细胞分裂的内源性抑制因子的存在是通过上皮损伤愈合和致癌作用的研究第一次被人们所证实的。这类起抑制性作用的生长调节因子被称为“抑素”,其特征是:(1)完全的组织特异性;(2)缺乏种属特异性;(3)可逆性。从实验角度考虑,发展抑素观点的主要困 Over the past decade, great progress has been made in the study of the structure and function of polypeptide hormones and their receptors on cell membranes, whereas the role of endogenous cytostatics Research has made little progress. The existence of endogenous inhibitors of cell division was first confirmed by studies of epithelial injury healing and carcinogenesis. Such inhibitory growth regulators are known as “somatostatin” and are characterized by: (1) complete tissue specificity; (2) lack of species-specificity; and (3) reversibility. From the experimental point of view, the main obstacle to the development of the concept of somatostatin