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目的研究原发性肝癌组织和细胞中叶酸受体α的表达情况,探讨其与肿瘤临床和病理特征的关系。方法采用免疫组织化学SP法检测原发性肝癌组织及细胞、肝硬化组织及正常肝组织中表达叶酸受体α的情况,分析原发性肝癌组织叶酸受体α表达与临床病理特征的关系。结果原发性肝癌组织中叶酸受体α表达率为88.9%(40/45),肝硬化组织为18.8%(6/32),正常肝组织中无叶酸受体α表达(0/20)。原发性肝癌组织叶酸受体α表达与患者性别、年龄等因素无相关性,但进展期患者阳性表达高于早-中期患者。结论原发性肝癌组织广泛高表达叶酸受体α,这为早期诊断及靶向药物治疗奠定了基础。
Objective To investigate the expression of folate receptor alpha in primary hepatocellular carcinoma (HCC) and its relationship with the clinical and pathological features of the tumor. Methods Immunohistochemistry SP method was used to detect the expression of folate receptor alpha in primary liver cancer tissues and cells, liver cirrhosis tissues and normal liver tissues. The relationship between the expression of folate receptor alpha and the clinicopathological features in primary liver cancer tissues was analyzed. Results The expression rate of folic acid receptor α was 88.9% (40/45) in primary hepatocellular carcinoma, 18.8% (6/32) in hepatic cirrhosis, and there was no expression of folate receptor α in normal liver tissue (0/20). There was no correlation between the expression of folate receptor alpha in primary hepatocellular carcinoma and the patient’s gender, age, etc., but the positive expression in patients with advanced hepatocellular carcinoma was higher than those in early-middle-phase patients. Conclusion Folic acid receptor α is widely expressed in primary liver cancer tissues, which lays a foundation for early diagnosis and targeted drug treatment.